Title | Indolent primary cutaneous γ/δ T-cell lymphoma localized to the subcutaneous panniculus and its association with atypical lymphocytic lobular panniculitis. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Magro CM, Wang X |
Journal | Am J Clin Pathol |
Volume | 138 |
Issue | 1 |
Pagination | 50-6 |
Date Published | 2012 Jul |
ISSN | 1943-7722 |
Keywords | Adult, Aged, Female, Humans, Lymphoma, T-Cell, Cutaneous, Middle Aged, Panniculitis, Receptors, Antigen, T-Cell, gamma-delta, Skin Neoplasms, Subcutaneous Tissue, T-Lymphocytes |
Abstract | The 2005 classification of lymphoma proposed the designation of subcutaneous panniculitis-like T-cell lymphoma exclusively for those tumors composed of α/β neoplastic cells. Subcutaneous lymphomas that comprised γ/δ T cells are termed primary cutaneous γ/δ T-cell lymphoma. The different clinical outcomes justified this separation; a more indolent course was characteristic of the α/β variants vs the poor 5-year survival of the γ/δ forms. We describe 5 patients with γ/δ T-cell lymphoma localized to the subcutis with a less aggressive clinical course. Two patients were alive 5 years after presentation, and in the remaining 3, the disease is in complete remission after simple intervention. Three patients had a waxing and waning phase, likely representing a prelymphomatous phase, which then progressed to an overt malignant tumor. Therefore, it is important to recognize that not all patients with γ/δ T-cell lymphomas have a poor prognosis. |
DOI | 10.1309/AJCPQGVLTZQ77VFF |
Alternate Journal | Am J Clin Pathol |
PubMed ID | 22706857 |
Related Faculty:
Cynthia M. Magro, M.D. Xuan Wang, M.D., Ph.D.