Indium-111 platelet kinetics in normal human subjects: tropolone versus oxine methods.

TitleIndium-111 platelet kinetics in normal human subjects: tropolone versus oxine methods.
Publication TypeJournal Article
Year of Publication1986
AuthorsVallabhajosula S, Machac J, Goldsmith SJ, Lipszyc H, Badimon L, Rand J, Fuster V
JournalJ Nucl Med
Date Published1986 Nov
KeywordsAdult, Blood Platelets, Cell Survival, Cycloheptanes, Female, Humans, Hydroxyquinolines, Indium, Male, Organometallic Compounds, Oxyquinoline, Radioisotopes, Time Factors, Tropolone

The effect of labeling media on the kinetics of[111In]platelets was evaluated by performing a paired crossover study in eight normal human subjects using tropolone and oxine methods. Platelets were labeled in autologous plasma with [111In]tropolone (In-tr) and in ACD-saline with [111In]oxine (In-ox) and reinjected. Starting at 1 hr, ten blood samples were obtained over an 8-day period. The in vivo platelet recovery was higher at 1 hr and throughout the 8 days of study with In-tr and the gamma camera images showed less uptake in liver and spleen than with In-ox. When platelet life-span (PLS) was estimated using all ten samples, only linear regression showed that the platelet life-span was longer with In-tr (10.7 +/- 1.5) than with In-ox (9.5 +/- 0.8). When the PLS was estimated excluding the 1-hr sample point, the life-span of platelets was significantly longer with In-tr than with In-ox based on three out of four models of curve fitting. These results demonstrate that platelets labeled with In-tr in plasma are preserved better in circulation and have equal or longer life-span than platelets labeled with In-ox in ACD-saline.

Alternate JournalJ Nucl Med
PubMed ID3095509
Related Faculty: 
Jacob H. Rand, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700