Human herpesvirus-8-associated lymphoma of the bowel in human immunodeficiency virus-positive patients without history of primary effusion lymphoma.

TitleHuman herpesvirus-8-associated lymphoma of the bowel in human immunodeficiency virus-positive patients without history of primary effusion lymphoma.
Publication TypeJournal Article
Year of Publication2002
AuthorsCostes V, Faumont N, Cesarman E, Rousset T, Meggetto F, Delsol G, Brousset P
JournalHum Pathol
Volume33
Issue8
Pagination846-9
Date Published2002 Aug
ISSN0046-8177
KeywordsAIDS-Related Opportunistic Infections, Herpesviridae Infections, Herpesvirus 4, Human, Herpesvirus 8, Human, Humans, Immunophenotyping, In Situ Hybridization, Intestinal Neoplasms, Lymphoma, AIDS-Related, Male, Mitosis, Polymerase Chain Reaction
Abstract

This report describes two cases of human herpesvirus-8 (HHV-8)-associated large cell lymphoma of the bowel in human immunodeficiency virus (HIV)-positive men. Immunohistochemistry provides evidence of HHV-8 infection of the lymphoma cells (LNA1+, vIL-6+). In both cases, lymphoma cells were coinfected by the Epstein-Barr virus. One case was of B-cell lineage, but the second one was of null phenotype with isolated expression of the CD3 molecule. However, in the latter case, assessment of B- or T-cell clonality remained elusive. The chief finding for these two cases was the lack of history of primary effusion lymphoma. There was an apparent restriction of the tumor to the large bowel in the first case. For the second case, the bowel tumor was preceded by lymph node and liver involvement. The cases suggest that the incidence of HHV-8 infection in large cell lymphoma arising in the setting of HIV infection (other than primary effusion lymphoma) may be underestimated and that the detection of the viral gene products would be appropriate for greater understanding of the pathogenesis of these tumors. HUM PATHOL 33:846-849.

DOI10.1053/hupa.2002.126184
Alternate JournalHum Pathol
PubMed ID12203218
Grant ListCA68939 / CA / NCI NIH HHS / United States
Related Faculty: 
Ethel Cesarman, M.D., Ph.D.

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