Title | Histone H1 mutations in lymphoma: a link(er) between chromatin organization, developmental reprogramming, and cancer. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Soshnev AA, C Allis D, Cesarman E, Melnick AM |
Journal | Cancer Res |
Date Published | 2021 Sep 27 |
ISSN | 1538-7445 |
Abstract | Aberrant cell fate decisions due to transcriptional misregulation are central to malignant transformation. Histones are the major constituents of chromatin, and mutations in histone-encoding genes are increasingly recognized as drivers of oncogenic transformation. Mutations in linker histone H1 genes were recently identified as drivers of peripheral lymphoid malignancy. Loss of H1 in germinal center B-cells results in widespread chromatin decompaction, redistribution of core histone modifications, and reactivation of stem cell-specific transcriptional programs. This review explores how linker histones and mutations therein regulate chromatin structure, highlighting reciprocal relationships between epigenetic circuits, and discusses the emerging role of aberrant three-dimensional chromatin architecture in malignancy. |
DOI | 10.1158/0008-5472.CAN-21-2619 |
Alternate Journal | Cancer Res |
PubMed ID | 34580064 |
Grant List | R01 CA204639 / CA / NCI NIH HHS / United States |
Related Faculty:
Ethel Cesarman, M.D., Ph.D.