| Title | Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Soshnev AA, Josefowicz SZ, C Allis D |
| Journal | Mol Cell |
| Volume | 62 |
| Issue | 5 |
| Pagination | 681-94 |
| Date Published | 2016 06 02 |
| ISSN | 1097-4164 |
| Keywords | Animals, Cell Transformation, Neoplastic, Chromatin Assembly and Disassembly, DNA Methylation, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Histones, Humans, Methylation, Models, Molecular, Mutation, Neoplasms, Nucleic Acid Conformation, Oncogenes, Phosphorylation, Protein Binding, Protein Conformation, Structure-Activity Relationship, Transcription, Genetic |
| Abstract | Information encoded in DNA is interpreted, modified, and propagated as chromatin. The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for transcriptional outcomes provided by the combinatorial and dynamic nature of epigenetic processes. Advances in genome editing, visualization technology, and genome-wide analyses have revealed unprecedented complexity of chromatin pathways, offering explanations to long-standing questions and presenting new challenges. Here, we review recent findings, exemplified by the emerging understanding of crossregulatory interactions within chromatin, and emphasize the pathologic outcomes of epigenetic misregulation in cancer. |
| DOI | 10.1016/j.molcel.2016.05.004 |
| Alternate Journal | Mol Cell |
| PubMed ID | 27259201 |
| PubMed Central ID | PMC4898265 |
| Grant List | K99 GM113019 / GM / NIGMS NIH HHS / United States P01 CA196539 / CA / NCI NIH HHS / United States R01 GM040922 / GM / NIGMS NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States |
Related Faculty:
Steven Josefowicz, Ph.D.