Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.

TitleGreater Than the Sum of Parts: Complexity of the Dynamic Epigenome.
Publication TypeJournal Article
Year of Publication2016
AuthorsSoshnev AA, Josefowicz SZ, C Allis D
JournalMol Cell
Volume62
Issue5
Pagination681-94
Date Published2016 06 02
ISSN1097-4164
KeywordsAnimals, Cell Transformation, Neoplastic, Chromatin Assembly and Disassembly, DNA Methylation, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Histones, Humans, Methylation, Models, Molecular, Mutation, Neoplasms, Nucleic Acid Conformation, Oncogenes, Phosphorylation, Protein Binding, Protein Conformation, Structure-Activity Relationship, Transcription, Genetic
Abstract

Information encoded in DNA is interpreted, modified, and propagated as chromatin. The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for transcriptional outcomes provided by the combinatorial and dynamic nature of epigenetic processes. Advances in genome editing, visualization technology, and genome-wide analyses have revealed unprecedented complexity of chromatin pathways, offering explanations to long-standing questions and presenting new challenges. Here, we review recent findings, exemplified by the emerging understanding of crossregulatory interactions within chromatin, and emphasize the pathologic outcomes of epigenetic misregulation in cancer.

DOI10.1016/j.molcel.2016.05.004
Alternate JournalMol Cell
PubMed ID27259201
PubMed Central IDPMC4898265
Grant ListK99 GM113019 / GM / NIGMS NIH HHS / United States
P01 CA196539 / CA / NCI NIH HHS / United States
R01 GM040922 / GM / NIGMS NIH HHS / United States
/ HHMI / Howard Hughes Medical Institute / United States
Related Faculty: 
Steven Josefowicz, Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700