G3BP1 modulates SPOP to promote prostate tumorigenesis.

TitleG3BP1 modulates SPOP to promote prostate tumorigenesis.
Publication TypeJournal Article
Year of Publication2022
AuthorsMukhopadhyay C, Zhou P
JournalMol Cell Oncol
Date Published2022

Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3SPOP), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However, it is unclear how the ubiquitin ligase activity of SPOP is controlled and how dysregulation of SPOP contributes to malignant transformation. Here, we identified GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) as an interactor and upstream regulator of CUL3SPOP, and it functions as an inhibitor of CUL3SPOP ubiquitin ligase, suggesting a distinctive mode of CUL3SPOP inactivation that aggravates prostate cancer.

Alternate JournalMol Cell Oncol
PubMed ID35252555
PubMed Central IDPMC8890399
Grant ListP50 CA211024 / CA / NCI NIH HHS / United States
R01 CA221152 / CA / NCI NIH HHS / United States
UL1 TR002384 / TR / NCATS NIH HHS / United States
Related Faculty: 
Pengbo Zhou, Ph.D.

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