Exploring a role for fatty acid synthase in prostate cancer cell migration.

TitleExploring a role for fatty acid synthase in prostate cancer cell migration.
Publication TypeJournal Article
Year of Publication2021
AuthorsDe Piano M, Manuelli V, Zadra G, Loda M, Muir G, Chandra A, Morris J, Van Hemelrijck M, Wells CM
JournalSmall GTPases
Date Published2021 Jul

Fatty acid synthase (FASN) is commonly overexpressed in prostate cancer and associated with tumour progression. FASN is responsible for synthesis of the fatty acid palmitate; the building block for protein palmitoylation. A functional role for FASN in regulating cell proliferation is widely accepted. We recently reported that FASN activity can also mediate prostate cancer HGF-mediated cell motility. Moreover, we found that modulation of FASN expression specifically impacts on the palmitoylation of RhoU. Findings we will describe here. We now report that loss of FASN expression also impairs HGF-mediated cell dissociation responses. Taken together our results provide compelling evidence that FASN activity directly promotes cell migration and supports FASN as a potential therapeutic target in metastatic prostate cancer.

Alternate JournalSmall GTPases
PubMed ID33043786
PubMed Central IDPMC8205051
Related Faculty: 
Massimo Loda, M.D.

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