| Title | Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. |
| Publication Type | Journal Article |
| Year of Publication | 1992 |
| Authors | Dominguez I, Diaz-Meco MT, Municio MM, Berra E, A de Herreros G, Cornet ME, Sanz L, Moscat J |
| Journal | Mol Cell Biol |
| Volume | 12 |
| Issue | 9 |
| Pagination | 3776-83 |
| Date Published | 1992 Sep |
| ISSN | 0270-7306 |
| Keywords | Amino Acid Sequence, Animals, Base Sequence, Cells, Cultured, DNA, Immunoblotting, Maturation-Promoting Factor, Molecular Sequence Data, Oocytes, Oogenesis, Protein Kinase C, RNA, Antisense, Signal Transduction, Tetradecanoylphorbol Acetate, Xenopus laevis |
| Abstract | A number of studies have demonstrated the activation of phospholipase C-mediated hydrolysis of phosphatidylcholine (PC-PLC) both by growth factors and by the product of the ras oncogene, p21ras. Evidence has been presented indicating that the stimulation of this phospholipid degradative pathway is sufficient to activate mitogenesis in fibroblasts as well as that it is sufficient and necessary for induction of maturation in Xenopus laevis oocytes. However, the mechanism whereby PC-PLC transduces mitogenic signals triggered by growth factors or oncogenes remains to be elucidated. In this study, data are presented that show the involvement of protein kinase C zeta subspecies in the channelling of the mitogenic signal activated by insulin-p21ras-PC-PLC in Xenopus oocytes as well as the lack of a critical role of protein kinase C isotypes alpha, beta, gamma, delta, and epsilon in these pathways. |
| DOI | 10.1128/mcb.12.9.3776-3783.1992 |
| Alternate Journal | Mol Cell Biol |
| PubMed ID | 1508183 |
| PubMed Central ID | PMC360243 |
Related Faculty:
Jorge Moscat, Ph.D. Maria Diaz-Meco Conde, Ph.D.