|Title||Differential expression of LFA-1 molecules in non-Hodgkin's lymphoma and lymphoid leukemia.|
|Publication Type||Journal Article|
|Year of Publication||1988|
|Authors||Inghirami G, Wieczorek R, Zhu BY, Silber R, Dalla-Favera R, Knowles DM|
|Date Published||1988 Oct|
|Keywords||Antigens, Differentiation, Antigens, Surface, B-Lymphocytes, Cell Adhesion Molecules, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphocyte Function-Associated Antigen-1, Lymphoma, Non-Hodgkin, Phenotype, T-Lymphocytes|
We investigated the expression of adherence molecules lymphocyte function-associated antigens-1 alpha and -beta (LFA-1 alpha, -beta) and p150, 95 in 103 well-characterized non-Hodgkin's lymphomas (NHLs) and lymphoid leukemias (LLs). We found that NHLs and LLs differentially express LFA-1 molecules according to their lineage derivation, degree of clinical aggressiveness, and anatomic site of involvement. Specifically, (a) T-cell neoplasms nearly always express these molecules; (b) diffuse aggressive B-cell NHLs and mature LLs often lack LFA-1 alpha molecules; and (c) B-cell chronic lymphocytic leukemia (CLL) is often LFA-1 alpha-negative while B-cell small lymphocytic lymphomas (SLLs) are nearly always LFA-1 alpha-positive. Furthermore, the low expression of LFA-1 alpha in CLL is related to the low degree of homotypic lymphocyte adhesion after tumor promoter antigen stimulation that does not modulate the expression of LFA-1 alpha in vitro. The differential expression of LFA-1 by B-cell CLL and SLL and their degree of homotypic lymphocyte adhesion may account for the distinct anatomic compartmentalization and characteristic clinical behavior of these two morphologically and immunologically similar lymphoid malignancies.
|Grant List||CA37295 / CA / NCI NIH HHS / United States |
CA48236 / CA / NCI NIH HHS / United States
EY06337 / EY / NEI NIH HHS / United States
Giorgio Inghirami, M.D.