The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer.

TitleThe cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer.
Publication TypeJournal Article
Year of Publication2001
AuthorsChiarle R, Pagano M, Inghirami G
JournalBreast Cancer Res
Date Published2001
KeywordsBreast Neoplasms, Cell Cycle Proteins, Cyclin D1, Cyclin-Dependent Kinase Inhibitor p27, Enzyme Inhibitors, Female, Humans, Immunohistochemistry, Lymph Nodes, Microtubule-Associated Proteins, Middle Aged, Multivariate Analysis, Prognosis, Proportional Hazards Models, Survival Analysis, Tumor Suppressor Proteins

p27 is an inhibitor of cyclin dependent kinase involved in the regulation of the cell cycle. In this commentary we discuss the current knowledge on p27 in breast cancer and its significance in predicting the outcome. p27 protein levels are high in most cases of breast carcinomas, are correlated with the levels of cyclin D1 and estrogen receptor, and could be a useful predictor of survival, because they are low in aggressive carcinomas. Immunodetection of p27 in breast tumors could be useful in the assessment of prognosis, especially in those cases in which the commonly used parameters are insufficient, and might ultimately influence the therapy of this disease.

Alternate JournalBreast Cancer Res
PubMed ID11250752
PubMed Central IDPMC139437
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