Concomitant calciphylaxis and COVID-19 associated thrombotic retiform purpura.

TitleConcomitant calciphylaxis and COVID-19 associated thrombotic retiform purpura.
Publication TypeJournal Article
Year of Publication2020
AuthorsRotman JA, Dean KE, Magro C, Nuovo G, Bartolotta RJ
JournalSkeletal Radiol
Date Published2020 Nov
KeywordsBetacoronavirus, Calciphylaxis, Computed Tomography Angiography, Coronavirus Infections, COVID-19, Diagnosis, Differential, Fatal Outcome, Female, Humans, Lower Extremity, Middle Aged, Pandemics, Pneumonia, Viral, Polymerase Chain Reaction, Purpura, SARS-CoV-2, Ultrasonography

While initial reports regarding coronavirus disease 2019 (COVID-19) focused on its pulmonary manifestations, more recent literature describes multisystem abnormalities related to its associated microvascular angiopathy. Calciphylaxis is a rare systemic condition characterized by tissue necrosis in the setting of systemic microvascular calcifications. Both COVID-19 and calciphylaxis are procoagulant diagnoses associated with vascular-mediated cutaneous findings. To our knowledge, this is the first report to document the coexistence of COVID-19 associated retiform thrombotic purpura and calciphylaxis in a single patient, to link the pathologic etiologies of the two entities, and to describe the concomitant diagnoses' associated radiologic findings.

Alternate JournalSkeletal Radiol
PubMed ID32844243
PubMed Central IDPMC7447529
Related Faculty: 
Cynthia M. Magro, M.D.


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