| Title | Clinicopathologic Characterization of Post-Renal Transplantation BK Polyomavirus-Associated Urothelial CarcinomaSingle Institutional Experience. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Chu Y-H, Zhong W, Rehrauer W, Pavelec DM, Ong IM, Arjang D, Patel SS, Hu R |
| Journal | Am J Clin Pathol |
| Volume | 153 |
| Issue | 3 |
| Pagination | 303-314 |
| Date Published | 2020 02 08 |
| ISSN | 1943-7722 |
| Keywords | Adult, Aged, BK Virus, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Female, Humans, Kidney, Kidney Neoplasms, Kidney Transplantation, Male, Middle Aged, Polyomavirus Infections, Postoperative Complications, Retrospective Studies, Tumor Virus Infections |
| Abstract | OBJECTIVES: To review rare cases of BK polyomavirus (BKPyV) associated urologic carcinomas in kidney transplant recipients at one institution and in the literature. METHODS: We describe the clinicopathologic features of BKPyV-associated urologic carcinomas in a single-institution cohort. RESULTS: Among 4,772 kidney recipients during 1994 to 2014, 26 (0.5%) and 26 (0.5%) developed posttransplantation urothelial carcinomas (UCs) and renal cell carcinomas (RCCs), respectively, as of 2017. Six (27%) UCs but none of the RCCs expressed large T antigen (TAg). TAg-expressing UCs were high grade with p16 and p53 overexpression (P < .05 compared to TAg-negative UCs). Tumor genome sequencing revealed BKPyV integration and a lack of pathogenic mutations in 50 cancer-relevant genes. Compared to TAg-negative UCs, TAg-expressing UCs more frequently presented at advanced stages (50% T3-T4) with lymph node involvement (50%) and higher UC-specific mortality (50%). CONCLUSIONS: Post-renal transplantation BKPyV-associated UCs are aggressive and genetically distinct from most non-BKPyV-related UCs. |
| DOI | 10.1093/ajcp/aqz167 |
| Alternate Journal | Am J Clin Pathol |
| PubMed ID | 31628837 |
Related Faculty:
Sanjay Patel, M.D., MPH