The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways.

TitleThe Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways.
Publication TypeJournal Article
Year of Publication2022
AuthorsChen Z, Tyler JK
JournalFront Cell Dev Biol
Date Published2022

DNA double-strand breaks (DSBs), the most deleterious DNA lesions, are primarily repaired by two pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ), the choice of which is largely dependent on cell cycle phase and the local chromatin landscape. Recent studies have revealed that post-translational modifications on histones play pivotal roles in regulating DSB repair pathways including repair pathway choice. In this review, we present our current understanding of how these DSB repair pathways are employed in various chromatin landscapes to safeguard genomic integrity. We place an emphasis on the impact of different histone post-translational modifications, characteristic of euchromatin or heterochromatin regions, on DSB repair pathway choice. We discuss the potential roles of damage-induced chromatin modifications in the maintenance of genome and epigenome integrity. Finally, we discuss how RNA transcripts from the vicinity of DSBs at actively transcribed regions also regulate DSB repair pathway choice.

Alternate JournalFront Cell Dev Biol
PubMed ID35757003
PubMed Central IDPMC9213757
Grant ListR01 CA095641 / CA / NCI NIH HHS / United States
R35 GM139816 / GM / NIGMS NIH HHS / United States
Related Faculty: 
Jessica K. Tyler, Ph.D.

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