| Title | Chaperoning histones during DNA replication and repair. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Ransom M, Dennehey BK, Tyler JK |
| Journal | Cell |
| Volume | 140 |
| Issue | 2 |
| Pagination | 183-95 |
| Date Published | 2010 Jan 22 |
| ISSN | 1097-4172 |
| Keywords | Animals, Chromatin Assembly and Disassembly, DNA Repair, DNA Replication, Histone Chaperones, Humans |
| Abstract | Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterward. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair. |
| DOI | 10.1016/j.cell.2010.01.004 |
| Alternate Journal | Cell |
| PubMed ID | 20141833 |
| PubMed Central ID | PMC3433953 |
| Grant List | R01 CA095641 / CA / NCI NIH HHS / United States R01 GM064475 / GM / NIGMS NIH HHS / United States T32 CA082086 / CA / NCI NIH HHS / United States |
Related Lab:
Related Faculty:
Jessica K. Tyler, Ph.D.