Chaperoning histones during DNA replication and repair.

TitleChaperoning histones during DNA replication and repair.
Publication TypeJournal Article
Year of Publication2010
AuthorsRansom M, Dennehey BK, Tyler JK
Date Published2010 Jan 22
KeywordsAnimals, Chromatin Assembly and Disassembly, DNA Repair, DNA Replication, Histone Chaperones, Humans

Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterward. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair.

Alternate JournalCell
PubMed ID20141833
PubMed Central IDPMC3433953
Grant ListR01 CA095641 / CA / NCI NIH HHS / United States
R01 GM064475 / GM / NIGMS NIH HHS / United States
T32 CA082086 / CA / NCI NIH HHS / United States
Related Faculty: 
Jessica K. Tyler, Ph.D.

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