Chaperoning histones during DNA replication and repair.

TitleChaperoning histones during DNA replication and repair.
Publication TypeJournal Article
Year of Publication2010
AuthorsRansom M, Dennehey BK, Tyler JK
JournalCell
Volume140
Issue2
Pagination183-95
Date Published2010 Jan 22
ISSN1097-4172
KeywordsAnimals, Chromatin Assembly and Disassembly, DNA Repair, DNA Replication, Histone Chaperones, Humans
Abstract

Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterward. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair.

DOI10.1016/j.cell.2010.01.004
Alternate JournalCell
PubMed ID20141833
PubMed Central IDPMC3433953
Grant ListR01 CA095641 / CA / NCI NIH HHS / United States
R01 GM064475 / GM / NIGMS NIH HHS / United States
T32 CA082086 / CA / NCI NIH HHS / United States
Related Faculty: 
Jessica K. Tyler, Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700