| Title | Cell Cycle Dysregulation in Mantle Cell Lymphoma: Genomics and Therapy. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Wang K, Huang X, Di Liberto M, Chen-Kiang S |
| Journal | Hematol Oncol Clin North Am |
| Volume | 34 |
| Issue | 5 |
| Pagination | 809-823 |
| Date Published | 2020 10 |
| ISSN | 1558-1977 |
| Keywords | Cyclin D1, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, G1 Phase Cell Cycle Checkpoints, Genomics, Humans, Lymphoma, Mantle-Cell, Piperazines, Pyridines |
| Abstract | Cell cycle dysregulation caused by aberrant cyclin D1 and CDK4 expression is a major determinant for proliferation of cancer cells in mantle cell lymphoma (MCL). Inhibition of CDK4/6 induces G1 arrest of MCL cells in patients, appearing to deepen and prolong the clinical response to partner agents. This article reviews aberrations of cell cycle genes in MCL cells and clinical trials of CDK4/6 inhibitors for MCL. Integrative longitudinal functional genomics is discussed as a strategy to discover genomic drivers for resistance in cancer cells and cancer-immune interactions that potentially contribute to the clinical response to palbociclib combination therapy in MCL. |
| DOI | 10.1016/j.hoc.2020.05.003 |
| Alternate Journal | Hematol Oncol Clin North Am |
| PubMed ID | 32861279 |
| PubMed Central ID | PMC7461610 |
| Grant List | P01 CA214274 / CA / NCI NIH HHS / United States |
Related Faculty:
Maurizio DiLiberto, Ph.D. Selina Chen-Kiang, Ph.D.