| Title | The B-cells that express anti-MAG antibodies in neuropathy and non-malignant IgM monoclonal gammopathy belong to the CD5 subpopulation. |
| Publication Type | Journal Article |
| Year of Publication | 1991 |
| Authors | Lee KW, Inghirami G, Spatz L, Knowles DM, Latov N |
| Journal | J Neuroimmunol |
| Volume | 31 |
| Issue | 1 |
| Pagination | 83-8 |
| Date Published | 1991 Jan |
| ISSN | 0165-5728 |
| Keywords | Antibodies, Antigens, CD20, Antigens, Differentiation, Antigens, Differentiation, B-Lymphocyte, B-Lymphocytes, Brain Diseases, CD5 Antigens, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Monoclonal Gammopathy of Undetermined Significance, Myelin Proteins, Myelin-Associated Glycoprotein |
| Abstract | B-cells that express monoclonal IgM anti-MAG antibodies (M-protein) in a patient with neuropathy and non-malignant IgM monoclonal gammopathy were studied by flow cytometry to determine if they bear the CD5 cell surface antigen. The CD5+ antigen is expressed on a subpopulation of B-cells which has been implicated in the secretion of autoantibodies and development of B-cell chronic lymphocytic leukemia (B-CLL). The monoclonal anti-MAG antibodies secreting B-cells were identified by a mouse monoclonal antibody to M-protein idiotype. Cytofluorometric analysis revealed that approximately 62% of the idiotype-positive B-lymphocytes expressed the CD5 antigen. The result of this study indicate that monoclonal anti-MAG antibodies may be secreted by CD5+ B-cells, and that B-cells in some cases of non-malignant IgM monoclonal gammopathy may be phenotypically similar to B-CLL cells. |
| DOI | 10.1016/0165-5728(91)90090-t |
| Alternate Journal | J Neuroimmunol |
| PubMed ID | 1701449 |
| Grant List | CA42836 / CA / NCI NIH HHS / United States NS11766 / NS / NINDS NIH HHS / United States NS25187 / NS / NINDS NIH HHS / United States |
Related Faculty:
Giorgio Inghirami, M.D.