Atypical hemolytic uremic syndrome after myomectomy: A case report.

TitleAtypical hemolytic uremic syndrome after myomectomy: A case report.
Publication TypeJournal Article
Year of Publication2022
AuthorsMusselman K, Laurence J, Magro C, Rahbari P, Di Vitantonio T, Havryliuk Y
JournalCase Rep Womens Health
Date Published2022 Jul

Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy due to inability to regulate the complement cascade, resulting in thrombocytopenia, intravascular hemolysis, and end-organ damage. Over 70% of cases are associated with mutations in complement or complement regulatory proteins, and some two-thirds have recognized complement-activating conditions triggering an aHUS event. We describe a case of aHUS after abdominal myomectomy in a 42-year-old woman that was managed with plasma exchange and eculizumab (an anti-C5 monoclonal antibody). The diagnosis was confirmed by biopsy of normal-appearing deltoid skin that demonstrated microvascular C5b-9 deposition, diagnostic of systemic complement pathway activation. Although extremely uncommon following gynecologic surgery, aHUS should be considered in the setting of postoperative oliguric acute kidney injury, as prompt diagnosis is necessary to prevent significant morbidity and mortality.

Alternate JournalCase Rep Womens Health
PubMed ID35769946
PubMed Central IDPMC9234065
Related Faculty: 
Cynthia M. Magro, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700