| Title | Annexin A5 levels in midtrimester amniotic fluid: association with intrauterine growth restriction. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Van Eerden P, Wu X-X, Chazotte C, Rand JH |
| Journal | Am J Obstet Gynecol |
| Volume | 194 |
| Issue | 5 |
| Pagination | 1371-6 |
| Date Published | 2006 May |
| ISSN | 1097-6868 |
| Keywords | Adult, Amniocentesis, Amniotic Fluid, Annexin A5, Cohort Studies, Enzyme-Linked Immunosorbent Assay, Female, Fetal Growth Retardation, Gestational Age, Humans, Linear Models, Pregnancy, Pregnancy Trimester, Second, Risk |
| Abstract | OBJECTIVE: The purpose of this study was to determine whether amniotic fluid levels of annexin A5 (AF-AnxA5) may be associated with intrauterine growth restriction (IUGR). STUDY DESIGN: Amniotic fluid was obtained in a cohort of pregnant patients (n = 172) undergoing amniocentesis at 15 to 24 weeks' gestation and annexin A5 (AnxA5) levels were determined with enzyme-linked immunosorbent assay (ELISA). Patients who developed IUGR were compared with the remainder of the cohort. RESULTS: AF-AnxA5 levels significantly increased through gestation (P = .003). The mean level of AF-AnxA5 in IUGR patients (n = 15) was significantly higher (P = .028) than in the remainder of the cohort (n = 130). Elevated AF-AnxA5 > 20 ng/mL was associated with a relative risk of 3.5 for the development of IUGR (P = .023). CONCLUSION: AnxA5 is present in amniotic fluid and increases through gestation from 15 to 24 weeks. Elevated AF-AnxA5 levels were present in patients who developed IUGR. AF-AnxA5 may be a useful marker for identifying pregnancy abnormalities. |
| DOI | 10.1016/j.ajog.2005.11.005 |
| Alternate Journal | Am J Obstet Gynecol |
| PubMed ID | 16579937 |
| Grant List | HL-61331 / HL / NHLBI NIH HHS / United States |
Related Faculty:
Jacob H. Rand, M.D.