Anaplastic lymphoma kinase: activating mechanisms and signaling pathways.

TitleAnaplastic lymphoma kinase: activating mechanisms and signaling pathways.
Publication TypeJournal Article
Year of Publication2015
AuthorsPizzi M, Gaudiano M, Todaro M, Inghirami G
JournalFront Biosci (Schol Ed)
Volume7
Pagination283-305
Date Published2015 Jun 01
ISSN1945-0524
KeywordsAnaplastic Lymphoma Kinase, Animals, Humans, Neoplasms, Receptor Protein-Tyrosine Kinases, Signal Transduction
Abstract

The discovery of Anaplastic Lymphoma Kinase (ALK) by Stephan Morris and colleagues twenty years ago has led to an unprecedented opportunity and provided the basis for a novel and clinically powerful stratification of human cancers. The molecular and biological characterization of ALK and the recognition of alternative mechanisms of activation of the tyrosine kinase receptors have then set the basis for the development and the subsequent application of selective small molecules. These achievements have fostered a new era in oncology, and the result of this new avenue has drastically changed the expectation of many cancer patients. Here we review the mechanisms of ALK activation and the modalities that drive ALK pathogenesis.

DOI10.2741/S441
Alternate JournalFront Biosci (Schol Ed)
PubMed ID25961703
Related Faculty: 
Giorgio Inghirami, M.D.

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