| Title | Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Davidson SM, Schmidt DR, Heyman JE, O'Brien JP, Liu AC, Israelsen WJ, Dayton TL, Sehgal R, Bronson RT, Freinkman E, Mak HH, Fanelli GNicolò, Malstrom S, Bellinger G, Carracedo A, Pandolfi PPaolo, Courtney KD, Jha A, DePinho RA, Horner JW, Thomas CJ, Cantley LC, Loda M, Heiden MGVander |
| Journal | Cancer Res |
| Volume | 82 |
| Issue | 13 |
| Pagination | 2403-2416 |
| Date Published | 2022 Jul 05 |
| ISSN | 1538-7445 |
| Keywords | Adenocarcinoma, Carcinogenesis, Humans, Male, Prostate, Prostatic Neoplasms, Pyruvate Kinase |
| Abstract | Differential expression of PKM1 and PKM2 impacts prostate tumorigenesis and suggests a potential therapeutic vulnerability in prostate cancer. |
| DOI | 10.1158/0008-5472.CAN-21-2352 |
| Alternate Journal | Cancer Res |
| PubMed ID | 35584006 |
| PubMed Central ID | PMC9256808 |
| Grant List | KL2 TR002542 / TR / NCATS NIH HHS / United States R01 CA168653 / CA / NCI NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States P30 CA014051 / CA / NCI NIH HHS / United States R35 CA242379 / CA / NCI NIH HHS / United States K08 CA136983 / CA / NCI NIH HHS / United States R35 CA197588 / CA / NCI NIH HHS / United States P50 CA090381 / CA / NCI NIH HHS / United States T32 GM007287 / GM / NIGMS NIH HHS / United States |
Related Faculty:
Massimo Loda, M.D.