Title | Characteristics of cutaneous marginal zone lymphomas with marked plasmacytic differentiation and a T cell-rich background. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Geyer JTurbiner, Ferry JA, Longtine JA, Flotte TJ, Harris NL, Zukerberg LR |
Journal | Am J Clin Pathol |
Volume | 133 |
Issue | 1 |
Pagination | 59-69 |
Date Published | 2010 Jan |
ISSN | 1943-7722 |
Keywords | Adult, Aged, Aged, 80 and over, Cell Transformation, Neoplastic, DNA, Neoplasm, Female, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Humans, In Situ Hybridization, Lymph Nodes, Lymphoma, B-Cell, Marginal Zone, Male, Middle Aged, Plasma Cells, Skin Neoplasms, T-Lymphocytes, Young Adult |
Abstract | Primary cutaneous marginal zone lymphoma (MZL) is a common B-cell lymphoma of skin and is characterized by an infiltrate of neoplastic marginal zone B cells typically within the marginal zones of reactive lymphoid follicles and the interfollicular region. However, in our experience, many cases have underemphasized features such as marked plasmacytic differentiation and/or a prominent T-cell component, which may obscure the neoplastic B cells and lead to misdiagnosis. We wanted to draw attention to these features and have studied 15 cases of MZL with marked plasmacytic differentiation, 10 of which had numerous T cells, some with cytologic atypia, and few B cells in the interfollicular region. Plasma cells were monotypic in all cases by in situ hybridization. By polymerase chain reaction, 6 of 8 T cell-rich cases had an IGH gene rearrangement, and none were clonal for T-cell receptor gene. We discuss the terminology, morphologic features, molecular profile, behavior, and differential diagnosis of cutaneous MZL. |
DOI | 10.1309/AJCPW64FFBTTPKFN |
Alternate Journal | Am J Clin Pathol |
PubMed ID | 20023259 |
Related Faculty:
Julia Geyer, M.D.