Epigenetic regulation of genomic integrity.

TitleEpigenetic regulation of genomic integrity.
Publication TypeJournal Article
Year of Publication2012
AuthorsDeem AK, Li X, Tyler JK
JournalChromosoma
Volume121
Issue2
Pagination131-51
Date Published2012 Apr
ISSN1432-0886
KeywordsChromatin Assembly and Disassembly, DNA Breaks, Double-Stranded, DNA Repair, Epigenesis, Genetic, Genomic Instability, Histones, Models, Biological
Abstract

Inefficient and inaccurate repair of DNA damage is the principal cause of DNA mutations, chromosomal aberrations, and carcinogenesis. Numerous multiple-step DNA repair pathways exist whose deployment depends on the nature of the DNA lesion. Common to all eukaryotic DNA repair pathways is the need to unravel the compacted chromatin structure to facilitate access of the repair machinery to the DNA and restoration of the original chromatin state afterward. Accordingly, our cells utilize a plethora of coordinated mechanisms to locally open up the chromatin structure to reveal the underlying DNA sequence and to orchestrate the efficient and accurate repair of DNA lesions. Here we review changes to the chromatin structure that are intrinsic to the DNA damage response and the available mechanistic insight into how these chromatin changes facilitate distinct stages of the DNA damage repair pathways to maintain genomic stability.

DOI10.1007/s00412-011-0358-1
Alternate JournalChromosoma
PubMed ID22249206
Related Faculty: 
Jessica K. Tyler, Ph.D.

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