Title | Diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Zhao Z, Moley KH, Gronowski AM |
Journal | Clin Biochem |
Volume | 46 |
Issue | 10-11 |
Pagination | 953-60 |
Date Published | 2013 Jul |
ISSN | 1873-2933 |
Keywords | Biomarkers, Female, Humans, MicroRNAs, Placenta, Pregnancy, Pregnancy Complications |
Abstract | Discovery of circulating miRNAs in maternal blood has not only facilitated the understanding of their role in normal pregnancy, but also paved new avenues for biomarker discovery to detect pregnancy-associated complications, such as preeclampsia, ectopic pregnancy, gestational diabetes mellitus, fetal growth restriction, recurrent pregnancy loss, and preterm delivery. In this review, we summarize the studies to date of miRNAs in maternal circulation and placental tissue in human. This brief review does not cover all aspects of this intriguing field but focuses on some new and interesting findings of diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases. |
DOI | 10.1016/j.clinbiochem.2013.01.026 |
Alternate Journal | Clin Biochem |
PubMed ID | 23396163 |
Related Faculty:
Zhen Zhao, Ph.D.