The annexinopathies: a new category of diseases.

TitleThe annexinopathies: a new category of diseases.
Publication TypeJournal Article
Year of Publication2000
AuthorsRand JH
JournalBiochim Biophys Acta
Date Published2000 Dec 20
KeywordsAnimals, Annexin A2, Annexin A5, Annexin A7, Antiphospholipid Syndrome, Calcium, Calcium Channels, Disease Models, Animal, Female, Fibrinolysis, Humans, Inositol 1,4,5-Trisphosphate Receptors, Insulin, Leukemia, Promyelocytic, Acute, Pre-Eclampsia, Pregnancy, Receptors, Cytoplasmic and Nuclear

The annexins are a family of highly homologous phospholipid binding proteins, which share a four-domain structure, with one member of the family - annexin VI - having a duplication consisting of eight domains. Thus far, ten annexins have been described in mammals. Although the biological functions of the annexins have not been definitively established, two human diseases involving annexin abnormalities ('annexinopathies') have been identified as of the time of writing. Overexpression of annexin II occurs in the leukocytes of a subset of patients having a hemorrhagic form of acute promyelocytic leukemia. Underexpression of annexin V occurs on placental trophoblasts in the antiphospholipid syndrome and in preeclampsia. Also, an animal model has been described in which annexin VII is underexpressed and is associated with disease, but the relevance of this animal model to human disease is not yet understood. Future research is likely to elucidate additional 'annexinopathies'.

Alternate JournalBiochim Biophys Acta
PubMed ID11108960
Grant ListHL-61331 / HL / NHLBI NIH HHS / United States
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