Woringer-Kolopp disease. A lymphomatoid hypersensitivity reaction.

TitleWoringer-Kolopp disease. A lymphomatoid hypersensitivity reaction.
Publication TypeJournal Article
Year of Publication1994
AuthorsCrowson AN, Magro CM
JournalAm J Dermatopathol
Date Published1994 Oct
KeywordsAdult, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Nucleus, Collagen, Cytoplasm, Epidermis, Female, Histiocytes, Humans, Hypersensitivity, Infant, Langerhans Cells, Lymphatic Diseases, Receptors, Antigen, T-Cell, Skin Neoplasms, T-Lymphocytes, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Helper-Inducer, T-Lymphocytes, Regulatory

We report two cases of unilesional pagetoid reticulosis (Woringer-Kolopp disease). Histopathological, immunohistological, ultrastructural, and genotypic studies showed both lesions to be lymphomatoid hypersensitivity reactions, as characterized by polyclonal proliferations of T-lymphocytes; CD8+ T cytotoxic-suppressor (Tc/s) lymphocytes were predominant in one case, whereas CD4+ T helper (Th) lymphocytes were predominant in the other. The nosology of Woringer-Kolopp disease is discussed.

Alternate JournalAm J Dermatopathol
PubMed ID7802169
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Cynthia M. Magro, M.D.

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