Synchronous water-clear cell double parathyroid adenomas a hitherto uncharacterized entity?

TitleSynchronous water-clear cell double parathyroid adenomas a hitherto uncharacterized entity?
Publication TypeJournal Article
Year of Publication2001
AuthorsKuhel WI, Gonzales D, Hoda SA, Pan L, Chiu A, Giri D, DeLellis RA
JournalArch Pathol Lab Med
Date Published2001 Feb
KeywordsAdenoma, Biopsy, Clone Cells, Female, Genetic Linkage, Humans, Hyperparathyroidism, Hyperplasia, Immunohistochemistry, Middle Aged, Parathyroid Glands, Parathyroid Hormone, Parathyroid Neoplasms, Polymerase Chain Reaction, Receptors, Androgen, Vacuoles, X Chromosome

Water-clear cell hyperplasia is a rare but well-documented cause of primary hyperparathyroidism. Parathyroid adenomas of the water-clear cell type are exceptionally rare, and only 2 cases have been reported. We describe a patient with synchronous water-clear cell double parathyroid adenomas, an entity that has not previously been reported. In our case, the enlarged superior parathyroid glands were completely replaced by water-clear cells, with only a minute rim of extracapsular, histologically unremarkable parathyroid tissue. The inferior parathyroid glands were grossly unremarkable, and incisional biopsy specimens were histologically normal (no foci of water-clear cells were identified). The findings in this case are most consistent with the diagnosis of double adenomas of the water-clear cell type. We acknowledge that despite molecular proof of monoclonality of the 2 lesions, it is not possible to entirely exclude the possibility that this unusual case could be due to asymmetric hyperplasia.

Alternate JournalArch Pathol Lab Med
PubMed ID11175646
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