Sphingosine-1-Phosphate Signaling in Endothelial Disorders.

TitleSphingosine-1-Phosphate Signaling in Endothelial Disorders.
Publication TypeJournal Article
Year of Publication2016
AuthorsSanchez T
JournalCurr Atheroscler Rep
Date Published2016 Jun
KeywordsEndothelium, Vascular, Humans, Lysophospholipids, Microvessels, Signal Transduction, Sphingosine, Vascular Diseases

Numerous preclinical studies indicate that sustained endothelial activation significantly contributes to tissue edema, perpetuates the inflammatory response, and exacerbates tissue injury ultimately resulting in organ failure. However, no specific therapies aimed at restoring endothelial function are available as yet. Sphingosine-1-phosphate (S1P) is emerging as a potent modulator of endothelial function and endothelial responses to injury. Recent studies indicate that S1PR are attractive targets to treat not only disorders of the arterial endothelium but also microvascular dysfunction caused by ischemic or inflammatory injury. In this article, we will review the current knowledge of the role of S1P and its receptors in endothelial function in health and disease, and we will discuss the therapeutic potential of targeting S1PR not only for disorders of the arterial endothelium but also the microvasculature. The therapeutic targeting of S1PR in the endothelium could help to bridge the gap between biomedical research in vascular biology and clinical practice.

Alternate JournalCurr Atheroscler Rep
PubMed ID27115142
Grant ListR01 HL094465 / HL / NHLBI NIH HHS / United States
HL094465 / HL / NHLBI NIH HHS / United States
Related Faculty: 
Teresa Sanchez, Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700