Role of fine-needle aspiration in clinical management of transplant patients.

TitleRole of fine-needle aspiration in clinical management of transplant patients.
Publication TypeJournal Article
Year of Publication1997
AuthorsSiddiqui MT, Reddy VB, Castelli MJ, Gattuso P
JournalDiagn Cytopathol
Date Published1997 Dec
KeywordsAdolescent, Adult, Biopsy, Needle, Cholestasis, Cytodiagnosis, Female, Humans, Inflammation, Lymphoproliferative Disorders, Male, Middle Aged, Neoplasms, Glandular and Epithelial, Organ Transplantation, Pulmonary Embolism, Sensitivity and Specificity, Soft Tissue Infections, Transplantation, Homologous

Fine-needle aspiration (FNA) of superficial and deep seated lesions has been used with high sensitivity and specificity in the diagnosis of neoplastic and non-neoplastic entities. However, studies of FNA in post-transplant patients are virtually absent. Six hundred and seventy-four allograft recipients (cardiac 288, renal 250, lung 131 and heart-lung 5) were reviewed. A total of 30 (25 heart, 4 lungs and 1 renal transplant) patients underwent an FNA procedure. There were 26 males and 4 females. Ages ranged from 18-63 yr (mean 48 yr). The most common entity aspirated was post-transplant lymphoproliferative disorder (PTLD) in 12 cases, followed by inflammatory lesions in 10 cases, malignant epithelial neoplasms in 3 cases, and 1 case each of malignant mesenchymal tumor, pulmonary infarction, hamartoma of liver, fatty changes of liver, and a benign vascular lesion. Surgical or autopsy tissue was available in 19 cases (63.3%). There was an agreement between tissue diagnosis and FNA material in 18 cases (94.7%). One (5.2%) false negative case was recorded. This was a liver aspirate showing benign liver elements, which a surgical biopsy proved to be a bile duct hamartoma. No false positive cases were recorded. FNA is a highly sensitive and specific diagnostic tool in the management of post-transplant patients.

Alternate JournalDiagn Cytopathol
PubMed ID9407203
Related Faculty: 
Momin Siddiqui, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
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