Reduced thrombogenicity of type VI collagen as compared to type I collagen.

TitleReduced thrombogenicity of type VI collagen as compared to type I collagen.
Publication TypeJournal Article
Year of Publication1995
AuthorsZangari M, Kaplan KL, Glanville RW, Rand JH
JournalThromb Res
Date Published1995 Sep 15
KeywordsCollagen, Endothelium, Vascular, Humans, Platelet Aggregation, Reference Values, Thrombosis, von Willebrand Factor

Type VI collagen has been recently identified as a major constituent of vascular subendothelium where it serves as a binding site for von Willebrand factor. The present study compares the functional characteristics of type VI collagen with those of type I collagen with respect to platelet aggregating and secretory activities. The differences between the two collagens in platelet aggregation and serotonin and beta-thromboglobulin release were found to be highly significant (p < 0.001, p < 0.0007, p < 0.005 respectively). Our results indicate that under in vitro conditions, type VI collagen stimulates a significantly lesser platelet activation and aggregation response than collagen I, suggesting that type VI collagen may play a role in vivo to limit the platelet thrombotic response following injury to the vascular subendothelium.

Alternate JournalThromb Res
PubMed ID7502269
Grant ListHL-32200 / HL / NHLBI NIH HHS / United States
Related Faculty: 
Jacob H. Rand, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700