Title | Primary CD20+CD10+CD8+ T-cell lymphoma of the skin with IgH and TCR beta gene rearrangement. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Magro CM, Seilstad KH, Porcu P, Morrison CD |
Journal | Am J Clin Pathol |
Volume | 126 |
Issue | 1 |
Pagination | 14-22 |
Date Published | 2006 Jul |
ISSN | 0002-9173 |
Keywords | Aged, Antigens, CD, Antigens, CD20, Antineoplastic Combined Chemotherapy Protocols, CD8 Antigens, Cyclophosphamide, Doxorubicin, Female, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Genes, T-Cell Receptor beta, Humans, Immunoglobulin Heavy Chains, Immunophenotyping, Lymphoma, T-Cell, Cutaneous, Neoplasm Recurrence, Local, Neprilysin, Prednisolone, Skin Neoplasms, T-Lymphocyte Subsets, Vincristine |
Abstract | Most cutaneous T-cell lymphomas are derived from mature postthymic T cells of the CD4 subtype. When other less common profiles are encountered, a diagnostic challenge is posed. Accurate categorization is critical because of the specificity of therapeutic regimens, including biologics. A 65-year-old woman was seen in 2001 because of a thigh mass manifesting an unusual phenotype eventually categorized as a mature postthymic CD8+ T-cell lymphoma with CD10 and weak CD20 expression. Molecular studies revealed T-cell receptor and heavy chain immunoglobulin rearrangement. Her cutaneous disease progressed despite several cycles of chemotherapy and radiation therapy. However, a therapeutic trial with denileukin diftitox resulted in a striking response. The importance of this case lies in the novel phenotype and dual T- and B-cell rearrangements. Rather than representing an aberrant phenotype, this tumor may represent the malignant counterpart of a benign population of weakly CD20+ T cells of the CD8 subset. |
DOI | 10.1309/HPYG-FLNX-KFBH-DQEV |
Alternate Journal | Am J Clin Pathol |
PubMed ID | 16753590 |
Related Faculty:
Cynthia M. Magro, M.D.