| Title | PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Boi M, Zucca E, Inghirami G, Bertoni F |
| Journal | Leuk Lymphoma |
| Volume | 56 |
| Issue | 5 |
| Pagination | 1223-8 |
| Date Published | 2015 May |
| ISSN | 1029-2403 |
| Keywords | Animals, B-Lymphocytes, Cell Transformation, Neoplastic, Humans, Lymphoma, B-Cell, Lymphoma, T-Cell, Positive Regulatory Domain I-Binding Factor 1, Repressor Proteins, T-Lymphocytes, Tumor Suppressor Proteins |
| Abstract | The gene encoding the human BLIMP1, prdm1, is located on chromosome 6q21, a locus frequently deleted in lymphoid tumors. BLIMP1 is able to silence its target genes in a context-dependent manner through different mechanisms. BLIMP1 is expressed in both B and T cells, in which it plays important functions. In B cells, BLIMP1 acts as the master regulator of plasma cell differentiation, repressed by BCL6 and repressing both BCL6 and PAX5. In T cells, BLIMP1 is a critical factor for most terminal effector cell differentiation in both CD4+ and CD8+ T cells. BLIMP1 is frequently inactivated in a variety of lymphomas, including diffuse large B cell lymphomas, Natural Killer cell lymphoma and anaplastic large T cell lymphoma. In this review, we will summarize the role of BLIMP1 in normal cells, focusing on lymphoid cells, and on its function as tumor suppressor gene in lymphomas. |
| DOI | 10.3109/10428194.2014.953155 |
| Alternate Journal | Leuk Lymphoma |
| PubMed ID | 25115512 |
Related Faculty:
Giorgio Inghirami, M.D.