Phospholipase C-diglyceride lipase is a major pathway for arachidonic acid release in macrophages.

TitlePhospholipase C-diglyceride lipase is a major pathway for arachidonic acid release in macrophages.
Publication TypeJournal Article
Year of Publication1986
AuthorsMoscat J, Herrero C, Garcia-Barreno P, Municio AM
JournalBiochem Biophys Res Commun
Volume141
Issue1
Pagination367-73
Date Published1986 Nov 26
ISSN0006-291X
KeywordsAnimals, Arachidonic Acid, Arachidonic Acids, Diglycerides, Kinetics, Lipoprotein Lipase, Macrophages, Male, Mice, Phospholipases A, Phospholipases A2, Type C Phospholipases
Abstract

Macrophages are a rich source of arachidonic acid oxygenated metabolites and play a remarkable role in a number of physiopathological situations. The synthesis and secretion of arachidonic acid metabolites are triggered at the cytoplasmic membrane level. The present study was outlined to further investigate the cellular mechanisms controlling arachidonic acid release in macrophages. The results presented here strongly suggest that the amount of arachidonic acid released in macrophages in response to phagocytic challenge could be accounted for by a phospholipase C-diglyceride lipase system being unnecessary the presence of phospholipase A2 whose activity, on the other hand, was found vanishingly small in macrophage homogenates.

DOI10.1016/s0006-291x(86)80378-3
Alternate JournalBiochem Biophys Res Commun
PubMed ID3099782
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