Title | Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Lee J, Zhou P |
Journal | Front Oncol |
Volume | 2 |
Pagination | 21 |
Date Published | 2012 |
ISSN | 2234-943X |
Abstract | The cullin 4-RING ubiquitin ligase (CRL4) family employs multiple DDB1-CUL4 associated factors substrate receptors to direct the degradation of proteins involved in a wide spectrum of cellular functions. Aberrant expression of the cullin 4A (CUL4A) gene is found in many tumor types, while mutations of the cullin 4B (CUL4B) gene are causally associated with human X-linked mental retardation. This focused review will summarize our current knowledge of the two CUL4 family members in the pathogenesis of human malignancy and neuronal disease, and discuss their potential as new targets for cancer prevention and therapeutic intervention. |
DOI | 10.3389/fonc.2012.00021 |
Alternate Journal | Front Oncol |
PubMed ID | 22649780 |
PubMed Central ID | PMC3355902 |
Grant List | R01 CA098210 / CA / NCI NIH HHS / United States R01 CA159925 / CA / NCI NIH HHS / United States |
Related Lab:
Related Faculty:
Pengbo Zhou, Ph.D.