Oxidative stress sensing and response in neural stem cell fate.

TitleOxidative stress sensing and response in neural stem cell fate.
Publication TypeJournal Article
Year of Publication2021
AuthorsHwang I, Tang D, Paik J
JournalFree Radic Biol Med
Date Published2021 06
KeywordsCell Differentiation, Neural Stem Cells, Oxidation-Reduction, Oxidative Stress, Signal Transduction

Neural stem/progenitor cells (NSPCs) contribute to the physiological cellular turnover of the adult brain and make up its regenerative potential. It is thus essential to understand how different factors influence their proliferation and differentiation to gain better insight into potential therapeutic targets in neurodegenerative diseases and traumatic brain injuries. Recent evidences indicate the roles of redox stress sensing and coping mechanisms in mediating the balance between NSPC self-renewal and differentiation. Such mechanisms involve direct cysteine modification, signaling and metabolic reprogramming, epigenetic alterations and transcription changes leading to adaptive responses like autophagy. Here, we discuss emerging findings on the involvement of redox sensors and effectors and their mechanisms in influencing changes in cellular redox potential and NSPC fate.

Alternate JournalFree Radic Biol Med
PubMed ID33862161
Related Faculty: 
Ji-Hye Paik, Ph.D.

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