N- and K-ras oncogenes in plasma cell dyscrasias.

TitleN- and K-ras oncogenes in plasma cell dyscrasias.
Publication TypeJournal Article
Year of Publication1994
AuthorsCorradini P, Ladetto M, Inghirami G, Boccadoro M, Pileri A
JournalLeuk Lymphoma
Date Published1994 Sep
KeywordsDNA Mutational Analysis, Genes, ras, Humans, Leukemia, Plasma Cell, Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, Paraproteinemias, Plasmacytoma, Point Mutation, Polymorphism, Single-Stranded Conformational, Prognosis

N- and K-ras oncogene mutations represent the most frequent molecular lesions in plasma cell dyscrasias. They are not randomly distributed since they are detectable in multiple myeloma (MM) (9-31%) and plasma cell leukemia (PCL) (30%), and not in monoclonal gammopathy of undetermined significance (MGUS) and solitary plasmacytoma (SP). Codons 12, 13 and 61 of N- and K-ras genes have been found mutated. Mutations affecting codon 61 of N-ras gene are the most frequent finding. A heterogeneous pattern of mutations is described with a prevalence of purine-pyrimidine transversions. Ras gene mutations have been predominantly detected in myelomas characterized by an advanced stage disease, and adverse prognostic parameters. These findings suggest that ras mutations represent a late molecular lesion and may be implicated in tumor progression rather than tumor initiation.

Alternate JournalLeuk Lymphoma
PubMed ID7858496
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