Metastatic Uterine Leiomyosarcoma With Rhabdomyosarcomatous Heterologous Differentiation.

TitleMetastatic Uterine Leiomyosarcoma With Rhabdomyosarcomatous Heterologous Differentiation.
Publication TypeJournal Article
Year of Publication2023
AuthorsBoyraz B, Gogakos T, Raskin KA, Nielsen GPetur
JournalInt J Gynecol Pathol
Date Published2023 Mar 01
KeywordsFemale, Humans, Leiomyosarcoma, Mutation, Pelvic Neoplasms, Rhabdomyosarcoma, Uterine Neoplasms

Heterologous differentiation has only been previously reported twice in metastatic uterine leiomyosarcomas. We report herein the first case of metastatic uterine leiomyosarcoma with rhabdomyosarcomatous differentiation. A 67-yr-old woman presented with femur, abductor magnus, and lymph node metastases 9 yr after the primary diagnosis. The metastatic sites showed rhabdomyosarcomatous morphologic features, and immunohistochemical studies confirmed skeletal muscle differentiation. Molecular testing revealed the same loss-of-function TP53 mutation in the uterine leiomyosarcoma and metastatic sites supporting heterologous differentiation of the primary tumor. Our case highlights the morphologic shifts metastatic tumors may manifest and the potential diagnostic problems that may arise.

Alternate JournalInt J Gynecol Pathol
PubMed ID35348494
Related Faculty: 
Baris Boyraz, M.D., Ph.D.

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