Localization of factor-VIII-related antigen in human vascular subendothelium.

TitleLocalization of factor-VIII-related antigen in human vascular subendothelium.
Publication TypeJournal Article
Year of Publication1980
AuthorsRand JH, Sussman II, Gordon RE, Chu SV, Solomon V
JournalBlood
Volume55
Issue5
Pagination752-6
Date Published1980 May
ISSN0006-4971
KeywordsAnimals, Antigens, Basement Membrane, Endothelium, Factor VIII, Fluorescent Antibody Technique, Humans, Microbial Collagenase, Platelet Adhesiveness, Rabbits, Saphenous Vein, Umbilical Cord, Umbilical Veins
Abstract

Factor-VIII-related antigen has previously been shown to be synthesized by vascular endothelial cells. Using both an immunofluorescent staining technique and electron microscopy, we have demonstrated the presence of factor-VIII-related antigen in human vascular subendothelium. This finding may have implications in the mechanism of platelet adhesion to deendothelialized blood vessel surfaces.

Alternate JournalBlood
PubMed ID6244867
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