Issues relating to lymphovascular invasion in breast carcinoma.

TitleIssues relating to lymphovascular invasion in breast carcinoma.
Publication TypeJournal Article
Year of Publication2006
AuthorsHoda SA, Hoda RS, Merlin S, Shamonki J, Rivera M
JournalAdv Anat Pathol
Volume13
Issue6
Pagination308-15
Date Published2006 Nov
ISSN1072-4109
KeywordsAdenocarcinoma, Breast Neoplasms, Female, Humans, Lymphatic Metastasis, Lymphatic System, Neoplasm Invasiveness
Abstract

Lymphovascular invasion (LVI) by tumor cells is histologically evident in approximately 15% of invasive mammary duct carcinomas and is present in approximately 10% of cases with pathologically negative lymph nodes. LVI is indicative of unfavorable prognosis in the breast cancer-as manifested by increased local failure and reduced overall survival. It is for this reason that LVI is routinely included in the evaluation and reporting of all breast cancers. There are a variety of interpretative difficulties in the histopathologic assessment of LVI, and the clinical implications of any misinterpretation can be profound. This brief review seeks to highlight the difficulties in the evaluation of LVI in breast cancer.

DOI10.1097/01.pap.0000213048.69564.26
Alternate JournalAdv Anat Pathol
PubMed ID17075296
Related Faculty: 
Syed Hoda, M.D.

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