Title | Invasive Paget disease of the nipple: a brief review of the literature and report of the first case with axillary nodal metastases. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Ozerdem U, Swistel A, Antonio LB, Hoda SA |
Journal | Int J Surg Pathol |
Volume | 22 |
Issue | 6 |
Pagination | 566-9 |
Date Published | 2014 Sep |
ISSN | 1940-2465 |
Keywords | Aged, Axilla, Breast Neoplasms, Carcinoma, Ductal, Breast, Female, Humans, Lymphatic Metastasis, Neoplasms, Second Primary, Nipples, Paget's Disease, Mammary |
Abstract | Although Paget disease of the nipple (PDN) is a well-established clinical and pathological neoplastic process, invasive PDN (IPDN) is a relatively newly described disease. The latter entity is characterized by invasive carcinoma that is localized to the nipple and is associated with PDN as well as with either intraductal and/or invasive carcinoma in the underlying breast. To our knowledge, only 17 cases of IPDN, all node negative, have been reported. Here, we report the case of a 68-year-old woman with invasive Paget disease of the left nipple. The patient had a history of intraductal carcinoma, treated by lumpectomy alone. She presented 6 years later with "eczematous" lesion of the ipsilateral nipple, a punch biopsy of which showed a superficially IPDN as well as conventional PDN. The subsequently performed wide excision of the nipple, areola, and underlying breast tissue showed the invasive carcinoma to span 0.6 cm. Then, 3 months later, the patient presented with ipsilateral palpable axillary lymphadenopathy. Axillary dissection revealed metastatic carcinoma in 7 of 19 lymph nodes. This case of IPDN not only represents the deepest extent of invasion reported thus far but also the only one known to be node positive. |
DOI | 10.1177/1066896914525229 |
Alternate Journal | Int J Surg Pathol |
PubMed ID | 24583835 |
Related Faculty:
Syed Hoda, M.D.