HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy.

TitleHIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy.
Publication TypeJournal Article
Year of Publication1999
AuthorsOrtiz GM, Nixon DF, Trkola A, Binley J, Jin X, Bonhoeffer S, Kuebler PJ, Donahoe SM, Demoitie MA, Kakimoto WM, Ketas T, Clas B, Heymann JJ, Zhang L, Cao Y, Hurley A, Moore JP, Ho DD, Markowitz M
JournalJ Clin Invest
Volume104
Issue6
PaginationR13-8
Date Published1999 Sep
ISSN0021-9738
KeywordsAcquired Immunodeficiency Syndrome, Adult, Anti-HIV Agents, HIV Core Protein p24, HIV-1, Humans, Male, Middle Aged, T-Lymphocytes, Cytotoxic, Viremia, Virus Replication
Abstract

Therapeutic intervention with highly active antiretroviral therapy (HAART) can lead to suppression of HIV-1 plasma viremia to undetectable levels for 3 or more years. However, adherence to complex drug regimens can prove problematic, and subjects may temporarily discontinue HAART for variable periods. We studied 6 HIV-1-infected individuals who stopped therapy. Off HAART, levels of viremia were suppressed to fewer than 500 copies/mL in 2 subjects for more than 12 and more than 24 months, respectively, and in 1 subject for 4 months on 1 occasion. Three subjects failed to contain plasma viremia. Broad and strong HIV-1-specific immune responses were detected in subjects with prolonged suppression of viral replication. This longitudinal study suggests that containment of HIV-1 replication to low or undetectable levels after discontinuation of HAART is associated with strong virus-specific immune responses. Boosting of HIV-1-specific immune responses should be considered as an adjunctive treatment strategy for HIV-1-infected individuals on HAART.

DOI10.1172/JCI7371
Alternate JournalJ Clin Invest
PubMed ID10491418
PubMed Central IDPMC408442
Grant ListM01 RR000102 / RR / NCRR NIH HHS / United States
R01 AI044595 / AI / NIAID NIH HHS / United States
MO1-RR000102 / RR / NCRR NIH HHS / United States
U01 AI041534 / AI / NIAID NIH HHS / United States
R37 AI036082 / AI / NIAID NIH HHS / United States
UO1AI41534 / AI / NIAID NIH HHS / United States
F31 GM020068 / GM / NIGMS NIH HHS / United States
R01 AI44595 / AI / NIAID NIH HHS / United States
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