Title | HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. |
Publication Type | Journal Article |
Year of Publication | 1999 |
Authors | Ortiz GM, Nixon DF, Trkola A, Binley J, Jin X, Bonhoeffer S, Kuebler PJ, Donahoe SM, Demoitie MA, Kakimoto WM, Ketas T, Clas B, Heymann JJ, Zhang L, Cao Y, Hurley A, Moore JP, Ho DD, Markowitz M |
Journal | J Clin Invest |
Volume | 104 |
Issue | 6 |
Pagination | R13-8 |
Date Published | 1999 Sep |
ISSN | 0021-9738 |
Keywords | Acquired Immunodeficiency Syndrome, Adult, Anti-HIV Agents, HIV Core Protein p24, HIV-1, Humans, Male, Middle Aged, T-Lymphocytes, Cytotoxic, Viremia, Virus Replication |
Abstract | Therapeutic intervention with highly active antiretroviral therapy (HAART) can lead to suppression of HIV-1 plasma viremia to undetectable levels for 3 or more years. However, adherence to complex drug regimens can prove problematic, and subjects may temporarily discontinue HAART for variable periods. We studied 6 HIV-1-infected individuals who stopped therapy. Off HAART, levels of viremia were suppressed to fewer than 500 copies/mL in 2 subjects for more than 12 and more than 24 months, respectively, and in 1 subject for 4 months on 1 occasion. Three subjects failed to contain plasma viremia. Broad and strong HIV-1-specific immune responses were detected in subjects with prolonged suppression of viral replication. This longitudinal study suggests that containment of HIV-1 replication to low or undetectable levels after discontinuation of HAART is associated with strong virus-specific immune responses. Boosting of HIV-1-specific immune responses should be considered as an adjunctive treatment strategy for HIV-1-infected individuals on HAART. |
DOI | 10.1172/JCI7371 |
Alternate Journal | J Clin Invest |
PubMed ID | 10491418 |
PubMed Central ID | PMC408442 |
Grant List | M01 RR000102 / RR / NCRR NIH HHS / United States R01 AI044595 / AI / NIAID NIH HHS / United States MO1-RR000102 / RR / NCRR NIH HHS / United States U01 AI041534 / AI / NIAID NIH HHS / United States R37 AI036082 / AI / NIAID NIH HHS / United States UO1AI41534 / AI / NIAID NIH HHS / United States F31 GM020068 / GM / NIGMS NIH HHS / United States R01 AI44595 / AI / NIAID NIH HHS / United States |
Related Faculty:
Jonas Heymann, M.D.