Histone and Chromatin Dynamics Facilitating DNA repair.

TitleHistone and Chromatin Dynamics Facilitating DNA repair.
Publication TypeJournal Article
Year of Publication2021
AuthorsMohan C, Das C, Tyler J
JournalDNA Repair (Amst)
Date Published2021 Nov

Our nuclear genomes are complexed with histone proteins to form nucleosomes, the repeating units of chromatin which function to package and limit unscheduled access to the genome. In response to helix-distorting DNA lesions and DNA double-strand breaks, chromatin is disassembled around the DNA lesion to facilitate DNA repair and it is reassembled after repair is complete to reestablish the epigenetic landscape and regulating access to the genome. DNA damage also triggers decondensation of the local chromatin structure, incorporation of histone variants and dramatic transient increases in chromatin mobility to facilitate the homology search during homologous recombination. Here we review the current state of knowledge of these changes in histone and chromatin dynamics in response to DNA damage, the molecular mechanisms mediating these dynamics, as well as their functional contributions to the maintenance of genome integrity to prevent human diseases including cancer.

Alternate JournalDNA Repair (Amst)
PubMed ID34419698
Related Faculty: 
Jessica K. Tyler, Ph.D.

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