Title | Hepatitis C virus reinfection in orthotopic liver transplant patients with or without concomitant hepatitis B infection. |
Publication Type | Journal Article |
Year of Publication | 1996 |
Authors | Loda M, Fiorentino M, Meckler J, Khettry U, Lewis D, Washburn K, Jenkins R, Mendoza AE, Samuelson J |
Journal | Diagn Mol Pathol |
Volume | 5 |
Issue | 2 |
Pagination | 81-7 |
Date Published | 1996 Jun |
ISSN | 1052-9551 |
Keywords | Base Sequence, Hepatitis B, Hepatitis C, Humans, Liver, Liver Function Tests, Liver Transplantation, Molecular Sequence Data, Polymerase Chain Reaction, Recurrence |
Abstract | Although recurrence of hepatitis C virus (HCV) in orthotopic liver transplant (OLT) patients is frequent, the relationship between HCV recurrence and graft pathology, particularly in patients who also have a history of hepatitis B virus (HBV), is unclear. The recurrence of HCV after OLT was determined by reverse transcriptase-nested polymerase chain reaction (RT-PCR) in the sera and livers of 41 patients with OLT, 32 of whom underwent transplants for HCV or HBV-related disease. Results were compared with liver function tests, liver histology (including HBV immunohistochemistry), and antibody status. HCV PCR was more frequently positive in OLT patients with a history of HCV only (59%) than in those with a history of both HCV and HBV (41%) or no history of viral infection (2%). Recurrent HCV (60% overall) was associated with mild elevation of liver function tests and mild to moderate hepatitis. In patients who underwent transplants for both HCV and HBV disease, hepatitis on biopsy was more frequently associated with recurrent HBV than with recurrent HCV. We conclude that graft reinfection with HCV, which is frequent in OLT patients with or without HBV recurrence, is usually associated with only mild to moderate hepatitic changes compatible with graft survival. |
DOI | 10.1097/00019606-199606000-00002 |
Alternate Journal | Diagn Mol Pathol |
PubMed ID | 8727094 |
Related Faculty:
Massimo Loda, M.D.