Giant cell tumor of the larynx. Case report and review of the literature.

TitleGiant cell tumor of the larynx. Case report and review of the literature.
Publication TypeJournal Article
Year of Publication1994
AuthorsMartin PC, Hoda SA, Pigman HT, Pulitzer DR
JournalArch Pathol Lab Med
Date Published1994 Aug
KeywordsAdult, Diagnosis, Differential, Giant Cell Tumors, Humans, Laryngeal Neoplasms, Male

Giant cell tumor of bone is rare in the osteocartilaginous tissues of the larynx. We describe a 23-year-old man with a 6-month history of progressive hoarseness and an enlarging neck mass. Computed tomography demonstrated a 4-cm mass with central cystic change arising in the right ala of the thyroid cartilage. A hemilaryngectomy was performed. Grossly, the lesion was expansile and circumscribed, but unencapsulated. On microscopic examination, numerous multinucleated giant cells were evenly dispersed within a cellular and vascular stroma. The findings were characteristic of giant cell tumor of bone. The patient has been disease free for 56 months. A review of the international literature yielded 11 cases. No lesion is known to have recurred after surgical excision, irradiation, or both. We present a clinicopathologic analysis of giant cell tumors involving the larynx and conclude that giant cell tumors are associated with a favorable clinical outcome.

Alternate JournalArch Pathol Lab Med
PubMed ID8060236
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