Gene expression correlates of clinical prostate cancer behavior.

TitleGene expression correlates of clinical prostate cancer behavior.
Publication TypeJournal Article
Year of Publication2002
AuthorsSingh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C, Tamayo P, Renshaw AA, D'Amico AV, Richie JP, Lander ES, Loda M, Kantoff PW, Golub TR, Sellers WR
JournalCancer Cell
Date Published2002 Mar
KeywordsAdult, Aged, Disease-Free Survival, Gene Expression Profiling, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prostatic Neoplasms, Reproducibility of Results, Risk Factors, Treatment Outcome

Prostate tumors are among the most heterogeneous of cancers, both histologically and clinically. Microarray expression analysis was used to determine whether global biological differences underlie common pathological features of prostate cancer and to identify genes that might anticipate the clinical behavior of this disease. While no expression correlates of age, serum prostate specific antigen (PSA), and measures of local invasion were found, a set of genes was identified that strongly correlated with the state of tumor differentiation as measured by Gleason score. Moreover, a model using gene expression data alone accurately predicted patient outcome following prostatectomy. These results support the notion that the clinical behavior of prostate cancer is linked to underlying gene expression differences that are detectable at the time of diagnosis.

Alternate JournalCancer Cell
PubMed ID12086878
Grant ListK23 CA089031 / CA / NCI NIH HHS / United States
K23 CA089031-02 / CA / NCI NIH HHS / United States
CA84995 / CA / NCI NIH HHS / United States
CA89031 / CA / NCI NIH HHS / United States
Related Faculty: 
Massimo Loda, M.D.

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