Title | Gastrointestinal stromal tumors I: pathology, pathobiology, primary therapy, and surgical issues. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Reichardt P, Hogendoorn PCW, Tamborini E, Loda M, Gronchi A, Poveda A, Schöffski P |
Journal | Semin Oncol |
Volume | 36 |
Issue | 4 |
Pagination | 290-301 |
Date Published | 2009 Aug |
ISSN | 0093-7754 |
Keywords | Gastrointestinal Stromal Tumors, Humans, Mutation, Oncogenes, Proto-Oncogene Proteins c-kit, Receptor, Platelet-Derived Growth Factor alpha |
Abstract | Gastrointestinal stromal tumor (GISTs) are the most common connective tissue malignancies of the gastrointestinal (GI) tract, with an incidence on the order of 10-13 per million people per year. Primary therapy is usually surgical, but the recurrence rate of large, so-called high-risk tumors, with a high mitotic rate, or those arising from small bowel and colon/rectum is particularly high. The natural history, pathology, and molecular biology of GISTs are discussed in this review, as are features of increasing our analytical power of the genes altered in these tumors, surgical issues, and the translation of research findings into clinical practice. The biological features of GIST make it a model for the examination of kinase-targeted therapeutics in solid tumors. |
DOI | 10.1053/j.seminoncol.2009.06.002 |
Alternate Journal | Semin Oncol |
PubMed ID | 19664490 |
Related Faculty:
Massimo Loda, M.D.