Functional properties of isolated hepatocytes from ethanol-treated rat liver.

TitleFunctional properties of isolated hepatocytes from ethanol-treated rat liver.
Publication TypeJournal Article
Year of Publication1985
AuthorsSchüller A, Moscat J, Diez E, Fernandez-Checa JC, Gavilanes FG, Municio AM
Date Published1985 Jul-Aug
KeywordsAnimals, Calcium, Cell Membrane, Ethanol, Fatty Liver, Alcoholic, Glucagon, Gluconeogenesis, Insulin, Liver, Methylation, Palmitates, Phosphatidylcholines, Phospholipids, Rats, Rats, Inbred Strains, Triglycerides

Gluconeogenesis and palmitate incorporation into triacylglycerols and phosphatidylcholine were measured in isolated hepatocytes from control and ethanol-treated rats. Basal gluconeogenesis and its hormonal response decreased in hepatocytes from ethanol-treated animals; palmitate incorporation into triacylglycerols increased. In ethanol-treated rat liver, 45Ca2+ uptake and methylating capacity were reduced, and the hormonal response exhibited differences in binding parameters of insulin.

Alternate JournalHepatology
PubMed ID3894201
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