|Title||Functional properties of isolated hepatocytes from ethanol-treated rat liver.|
|Publication Type||Journal Article|
|Year of Publication||1985|
|Authors||Schüller A, Moscat J, Diez E, Fernandez-Checa JC, Gavilanes FG, Municio AM|
|Date Published||1985 Jul-Aug|
|Keywords||Animals, Calcium, Cell Membrane, Ethanol, Fatty Liver, Alcoholic, Glucagon, Gluconeogenesis, Insulin, Liver, Methylation, Palmitates, Phosphatidylcholines, Phospholipids, Rats, Rats, Inbred Strains, Triglycerides|
Gluconeogenesis and palmitate incorporation into triacylglycerols and phosphatidylcholine were measured in isolated hepatocytes from control and ethanol-treated rats. Basal gluconeogenesis and its hormonal response decreased in hepatocytes from ethanol-treated animals; palmitate incorporation into triacylglycerols increased. In ethanol-treated rat liver, 45Ca2+ uptake and methylating capacity were reduced, and the hormonal response exhibited differences in binding parameters of insulin.
Jorge Moscat, Ph.D.