Fucoidan is a non-anticoagulant inhibitor of intimal hyperplasia.

TitleFucoidan is a non-anticoagulant inhibitor of intimal hyperplasia.
Publication TypeJournal Article
Year of Publication1992
AuthorsMcCaffrey TA, Falcone DJ, Borth W, Brayton CF, Weksler BB
JournalBiochem Biophys Res Commun
Date Published1992 Apr 30
KeywordsAnimals, Anions, Aorta, Cattle, Cell Division, Cells, Cultured, Dose-Response Relationship, Drug, Heparin, Hyperplasia, Muscle, Smooth, Vascular, Polysaccharides, Rats, Rats, Inbred F344, Receptors, Cell Surface, Receptors, Transforming Growth Factor beta, Transforming Growth Factor beta

We previously reported that heparin inhibits the proliferation of fibroblasts and vascular smooth muscle cells (SMC), in part, by binding to and increasing the antiproliferative activity of transforming growth factor-beta 1 (TGF-beta 1). We now report that certain other polyanions which are structurally distinct from heparin, such as fucoidan and polyinosinic acid, are more avid ligands for TGF-beta 1 and more potent antiproliferative agents than heparin. Fucoidan possessed more potent antiproliferative activity than heparin against rat and bovine aortic SMC in vitro, though possessing much lower anticoagulant activity than heparin. Furthermore, fucoidan suppressed in vivo intimal hyperplasia when continuously infused into rats subjected to balloon-catheter injury. Unlike heparin, which also suppressed intimal hyperplasia, fucoidan did not cause systemic anticoagulation. Thus, fucoidan may be useful as a non-anticoagulant inhibitor of post-angioplasty intimal hyperplasia.

Alternate JournalBiochem Biophys Res Commun
PubMed ID1315533
Grant ListHL01962 / HL / NHLBI NIH HHS / United States
HL35724 / HL / NHLBI NIH HHS / United States
HL42606 / HL / NHLBI NIH HHS / United States
Related Faculty: 
Domenick J. Falcone, Ph.D.

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