Epithelioid variant of malignant peripheral nerve sheath tumor (malignant schwannoma) of the urinary bladder.

TitleEpithelioid variant of malignant peripheral nerve sheath tumor (malignant schwannoma) of the urinary bladder.
Publication TypeJournal Article
Year of Publication1999
AuthorsEltoum IA, Moore RJ, Cook W, Crowe DR, Rodgers WH, Siegal GP
JournalAnn Diagn Pathol
Date Published1999 Oct
KeywordsAbscess, Adult, Ascitic Fluid, Biomarkers, Tumor, Diagnosis, Differential, Epithelioid Cells, Hematoma, Humans, Immunoenzyme Techniques, Male, Neurilemmoma, Peripheral Nervous System, Tomography, X-Ray Computed, Urinary Bladder Neoplasms

Sarcoma represents less than 2% of all neoplasms diagnosed or recognized in effusions. Epithelioid peripheral nerve sheath tumor is a rare tumor that is difficult to differentiate from other epithelioid tumors without the use of ancillary studies. A 39-year-old paraplegic man presented with hematuria and a bladder mass that extended to involve the pelvic peritoneum. Light microscopy using hematoxylin-eosin, Papanicolaou, and immunohistochemical stains as well as transmission electron microscopy showed features of epithelioid malignant peripheral nerve sheath tumor with rhabdoid features and an accompanying eosinophilic infiltrate. Cytologic smears confirmed the similarities between the primary tumor in the bladder and the cells in the pelvic fluid and excluded the possibility of reactive changes related to postsurgical radiation. Ancillary studies were critical in narrowing the differential diagnoses and reaching the final conclusion.

Alternate JournalAnn Diagn Pathol
PubMed ID10556478
Related Faculty: 
William Rodgers, M.D., Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700