|Title||Distribution of von Willebrand factor in porcine intima varies with blood vessel type and location.|
|Publication Type||Journal Article|
|Year of Publication||1987|
|Authors||Rand JH, Badimon L, Gordon RE, Uson RR, Fuster V|
|Date Published||1987 May-Jun|
|Keywords||Animals, Arteries, Blood Platelets, Endothelium, Fluorescent Antibody Technique, Pulmonary Veins, Swine, Veins, von Willebrand Factor|
The von Willebrand factor (vWF) has been generally accepted as a marker for endothelial cells. In a systematic immunolocalization study of porcine blood vessels that used indirect immunofluorescence with a monospecific polyclonal anti-vWF and two monoclonal anti-vWFs, we observed that vWF is not universally distributed in intact, fresh endothelia. vWF is consistently localized in veins, with the exception of the pulmonic vein. In arteries, vWF is generally absent except for areas of the distal abdominal aorta, the vaso vasorum of the thoracic aorta, and the pulmonic artery. We conclude that there are regional differences in the distribution of vWF in the various endothelial beds of pigs.
|Grant List||HL-17430 / HL / NHLBI NIH HHS / United States |
HL-32200 / HL / NHLBI NIH HHS / United States
Jacob H. Rand, M.D.