| Title | Defective annexin A5 crystallization: a mechanism for pregnancy losses in the antiphospholipid syndrome. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Rand J, Eerden PV, Wu XX, Chazotte C |
| Journal | Thromb Res |
| Volume | 115 Suppl 1 |
| Pagination | 77-81 |
| Date Published | 2005 Feb |
| ISSN | 0049-3848 |
| Keywords | Abortion, Spontaneous, Animals, Annexin A5, Antiphospholipid Syndrome, Autoantibodies, Crystallization, Female, Humans, Microscopy, Atomic Force, Pregnancy, Trophoblasts |
| Abstract | We have accumulated a significant body of evidence that support the hypothesis that aPL antibody-mediated disruption of annexin A5 crystallization is a mechanism for RSPL in the APS. Further investigation of the functions of the annexins in placental physiology and disease are likely to be productive areas for future research. |
| Alternate Journal | Thromb Res |
| PubMed ID | 15790162 |
| Grant List | HL-61331 / HL / NHLBI NIH HHS / United States |
Related Faculty:
Jacob H. Rand, M.D.